By Frances M. Ashcroft
Ion channels are membrane proteins that act as gated pathways for the stream of ions throughout mobile membranes. They play crucial roles within the body structure of all cells. lately, an ever-increasing variety of human and animal illnesses were discovered to consequence from defects in ion channel functionality. each one of these illnesses come up from mutations within the genes encoding ion channel proteins, and they're now often called the channelopathies.
Ion Channels and Disease presents an informative and up to date account of our current figuring out of ion channels and the molecular foundation of ion channel illnesses. It incorporates a simple advent to the appropriate elements of molecular biology and biophysics and a short description of the important equipment used to check channelopathies. for every channel, the connection among its molecular constitution and its sensible houses is mentioned and ways that genetic mutations produce the sickness phenotype are thought of.
This ebook is meant for examine employees and clinicians, in addition to graduates and complicated undergraduates. The textual content is apparent and vigorous and assumes little wisdom, but it takes the reader to frontiers of what's presently identified approximately this most enjoyable and medically very important quarter of body structure.
* Introduces the proper features of molecular biology and biophysics
* Describes the primary equipment used to check channelopathies
* Considers unmarried periods of ion channels with summaries of the physiological function, subunit composition, molecular constitution and chromosomal position, plus the connection among channel constitution and function
* appears to be like at these illnesses linked to faulty channel constructions and rules, together with mutations affecting channel functionality and to what quantity this transformation in channel functionality can account for the medical phenotype
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