By J. D. Winefordner(eds.)
Caliber size, keep an eye on, and development in combinatorial chemistry
Combinatorial chemistry has constructed swiftly long ago decade, with nice advances made by means of scientists engaged on research and purification of a big variety of compounds and the research of polymer-bound compounds. besides the fact that, ambitious demanding situations lie sooner than modern day researcher. for instance, high-throughput research and purification applied sciences needs to be additional constructed to make sure combinatorial libraries are "purifiable," and "drugable."
To this finish, research and Purification equipment in Combinatorial Chemistry describes a variety of analytical recommendations and platforms for the improvement, validation, quality controls, purification, and physicochemical trying out of combinatorial libraries. a brand new quantity in Wiley's Chemical research sequence, this article has 4 elements covering:
* quite a few techniques to tracking reactions on stable help and optimizing reactions for library synthesis
* High-throughput analytical tools used to investigate the standard of libraries
* High-throughput purification techniques
* Analytical tools utilized in post-synthesis and post-purification stages
Drawing from the contributions of revered specialists in combinatorial chemistry, this complete e-book offers assurance of functions of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier remodel Infrared (FTIR), micellar electrokinetic chromatography (MEKC) applied sciences, in addition to different analytical techniques.
This eminently helpful quantity is a vital addition to the library of scholars and researchers learning or operating in analytical chemistry, combinatorial chemistry, medicinal chemistry, natural chemistry, biotechnology, biochemistry, or biophysics.Content:
Chapter 1 Quantitative research in natural Synthesis with NMR Spectroscopy (pages 1–36): Laura H. Lucas and Cynthia okay. Larive
Chapter 2 19F Gel?Phase NMR Spectroscopy for response tracking and Quantification of Resin Loading (pages 37–51): Joseph M. Salvino
Chapter three the applying of Single?Bead FTIR and colour attempt for response tracking and construction Block Validation in Combinatorial Library Synthesis (pages 53–69): Jason J. Cournoyer, Clinton A. Krueger, Janice V. Wade and Bing Yan
Chapter four HR?MAS NMR research of Compounds hooked up to Polymer helps (pages 71–86): Meritxell Guino and Yolanda R. de Miguel
Chapter five Multivariate instruments for Real?Time tracking and Optimization of Combinatorial fabrics and strategy stipulations (pages 87–123): Radislav A. Potyrailo, Ronald J. Wroczynski, John P. Lemmon, William P. Flanagan and Oltea P. Siclovan
Chapter 6 Mass Spectrometry and Soluble Polymeric aid (pages 125–135): Christine Enjalbal, Frederic Lamaty, Jean Martinez and Jean?Louis Aubagnac
Chapter 7 High?Throughput NMR strategies for Combinatorial Chemical Library research (pages 137–173): Ting Hou and Daniel Raftery
Chapter eight Micellar Electrokinetic Chromatography as a device for Combinatorial Chemistry research: thought and purposes (pages 175–208): Peter J. Simms
Chapter nine Characterization of Split?Pool Encoded Combinatorial Libraries (pages 209–252): Jing Jim Zhang and William L. Fitch
Chapter 10 concepts and strategies for Purifying natural Compounds and Combinatorial Libraries (pages 253–280): Jiang Zhao, Lu Zhang and Bing Yan
Chapter eleven High?Throughput Purification: Triage and Optimization (pages 281–306): Jill Hochlowski
Chapter 12 Parallel HPLC in High?Throughput research and Purification (pages 307–320): Ralf God and Holger Gumm
Chapter thirteen natural Compound balance in huge, diversified Pharmaceutical Screening Collections (pages 321–350): Kenneth L. Morand and Xueheng Cheng
Chapter 14 Quartz Crystal Microbalance in Biomolecular reputation (pages 351–368): Ming?Chung Tseng, I?Nan Chang and Yen?Ho Chu
Chapter 15 High?Throughput Physicochemical Profiling: strength and obstacles (pages 369–406): Bernard Faller
Chapter sixteen Solubility within the layout of Combinatorial Libraries (pages 407–434): Christopher Lipinski
Chapter 17 High?Throughput decision of Log D Values by way of LC/MS procedure (pages 435–455): Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt and James J. Bao
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